Look at alternant therapies that aren't reasonable CYP3A inducers through cure with mitapivat. If unable to avoid coadministration, keep an eye on Hb and titrate over and above 50 mg BID, if essential, but don't exceed mitapivat dose of 100 mg BID. .pentobarbital will decrease the level or effect of conivaptan by affecting hepatic/intestinal enzyme